Metilfenidato: Propiedades, aplicaciones y controversias
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Palabras clave

Metilfenidato
TDAH
Estimulantes
Recompensa
Controversias

Cómo citar

Quintanilla Calvi, J. P., & Escobar Cornejo, G. S. (2022). Metilfenidato: Propiedades, aplicaciones y controversias. Revista De Psicología, 12(1), 189–203. https://doi.org/10.36901/psicologia.v12i1.1479

Resumen

El metilfenidato es un fármaco de primera línea para el tratamiento del Trastorno de Déficit de Atención e Hiperactividad (TDAH), aunque su uso no ese limita a este. Se comercializa desde 1954, habiéndose generado gran cantidad de conocimiento acerca de su funcionamiento y efectividad, así como también controversias acerca de su uso. Se presenta una revisión que incluye todos los aspectos que deben ser conocidos por los profesionales que trabajan con pacientes medicados con este fármaco. Abarcamos los mecanismos de acción, farmacodinámica, indicaciones y efectos secundarios, así como las interacciones que puede tener con otros fármacos y el uso que se le da al medicamento fuera del sistema de salud (como mejorador de la cognición). También se revisa la efectividad de este medicamento en el tratamiento del TDAH y las controversias y malentendidos que han ido surgiendo respecto a su utilización en pacientes pediátricos. Así mismo, se dedica un breve apartado a la interacción de este fármaco con el sistema de recompensa del cerebro, y la posibilidad de generar dependencias al compuesto.

https://doi.org/10.36901/psicologia.v12i1.1479
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Adams, J., Alipio-Jocson, V., Inoyama, K., Bartlett, V., Sandhu, S., Oso, J., Barry, J. J., Loring, D. W., & Meador, K. (2017). Methylphenidate, cognition, and epilepsy: A double-blind, placebo-controlled, single-dose study. Neurology, 88(5), 470-476.

Arnsten, A. F. (2006). Stimulants: Therapeutic actions in ADHD. Neuropsychopharmacology, 31(11), 2376-2383.

Bartl, J., Palazzesi, F., Parrinello, M., Hommers, L., Riederer, P., Walitza, S., & Grünblatt, E. (2017). The impact of methylphenidate and its enantiomers on dopamine synthesis and metabolism in vitro. Progress in Neuro-psychopharmacology and Biological Psychiatry, 79, 281-288.

Barra, F. E. de la, Vicente, B., Saldivia, S., & Melipillan, R. (2013). Epidemiology of ADHD in Chilean children and adolescents. ADHD Attention Deficit and Hyperactivity Disorders, 5(1), 1-8. https://doi.org/10.1007/s12402-012-0090-6

Briars, L., & Todd, T. (2016). A review of pharmacological management of attention-deficit/hyperactivity disorder. The Journal of Pediatric Pharmacology and Therapeutics, 21(3), 192-206.

Challman, T. D., & Lipsky, J. J. (2000). Methylphenidate: Its pharmacology and uses. Mayo Clinic Proceedings, 75(7), 711-721.

Chan, E., Fogler, J. M., & Hammerness, P. G. (2016). Treatment of attention-deficit/ hyperactivity disorder in adolescents: A systematic review. Jama, 315(18), 1997-2008.

Cortese, S., Adamo, N., Del Giovane, C., Mohr-Jensen, C., Hayes, A. J., Carucci, S., Atkinson, L. Z., Tessari, L., Banaschewski, T., & Coghill, D. (2018). Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: A systematic review and network meta-analysis. The Lancet Psychiatry, 5(9), 727-738.

Dürsteler, K. M., Berger, E.-M., Strasser, J., Caflisch, C., Mutschler, J., Herdener, M., & Vogel, M. (2015). Clinical potential of methylphenidate in the treatment of cocaine addiction: A review of the current evidence. Substance abuse and rehabilitation, 6, 61-74. https://doi.org/10.2147/SAR.S50807

Epstein, T., Patsopoulos, N. A., & Weiser, M. (2014). Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults. Cochrane Database of Systematic Reviews, 18(9). https://doi.org/10.1002/14651858.CD005041.pub2

Faraone, S. V. (2018). The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities. Neuroscience & Biobehavioral Reviews, 87, 255-270.

Faraone, S. V., & Larsson, H. (2019). Genetics of attention deficit hyperactivity disorder. Molecular Psychiatry, 24(4), 562-575.

Findling, R. L., & Dinh, S. (2014). Transdermal therapy for attention-deficit hyperactivity disorder with the methylphenidate patch (MTS). CNS drugs, 28(3), 217-228.

Floren, S., King, N., Carrasco, A., & Dafny, N. (2020). Glutamate and dopamine in the VTA participate differently in the acute and chronic effect of methylphenidate. Behavioural Brain Research, 380, 112390.

Fond, G., Micoulaud-Franchi, J. A., Macgregor, A., Richieri, R., Miot, S., Lopez, R., Abbar, M., Lancon, C., & Repantis, D. (2015). Neuroenhancement in healthy adults, part I: Pharmaceutical cognitive enhancement: a systematic review. Journal of Clinical Research & Bioethics, 6(2), 1000213. https://doi.org/10.4172/2155-9627.1000213

Freese, L., Signor, L., Machado, C., Ferigolo, M., & Barros, H. M. T. (2012). Non-medical use of methylphenidate: A review. Trends in Psychiatry and Psychotherapy, 34(2), 110-115.

García, J. M. S., & Durán, J. M. M. (2005). Medicamentos estimulantes en el tratamiento del TDAH. Plasticidad y restauración neurológica, 4(1-2), 75-80.

Holmskov, M., Storebø, O. J., Moreira-Maia, C. R., Ramstad, E., Magnusson, F. L., Krogh, H. B., Groth, C., Gillies, D., Zwi, M., & Skoog, M. (2017). Gastrointestinal adverse events during methylphenidate treatment of children and adolescents with attention deficit hyperactivity disorder: A systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials. PloS One, 12(6), e0178187. https://doi.org/10.1371/journal.pone.0178187

Israel, J. A. (2015). Combining stimulants and monoamine oxidase inhibitors: A reexamination of the literature and a report of a new treatment combination.

The Primary Care Companion for CNS Disorders, 17(6). https://doi.org/10.4088/ PCC.15br01836

Kim, Y., Teylan, M. A., Baron, M., Sands, A., Nairn, A. C., & Greengard, P. (2009). Methylphenidate-induced dendritic spine formation and ΔFosB expression in nucleus accumbens. Proceedings of the National Academy of Sciences, 106(8), 2915-2920.

Kolar, D., Keller, A., Golfinopoulos, M., Cumyn, L., Syer, C., & Hechtman, L. (2008).

Treatment of adults with attention-deficit/hyperactivity disorder. Neuropsychiatric Disease and Treatment, 4(2), 389-403. https://doi.org/10.2147/ndt.s6985

Kortekaas-Rijlaarsdam, A. F., Luman, M., Sonuga-Barke, E., & Oosterlaan, J. (2019). Does methylphenidate improve academic performance? A systematic review and meta-analysis. European Child & Adolescent Psychiatry, 28(2), 155-164.

Man, K. K., Coghill, D., Chan, E. W., Lau, W. C., Hollis, C., Liddle, E., Banaschewski, T., McCarthy, S., Neubert, A., & Sayal, K. (2016). Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system. Translational Psychiatry, 6(11), e956. https://doi.org/10.1038/ tp.2016.216

Mardomingo-Sanz, M. J. (2012). Uso clínico de metilfenidato 30: 70 de liberación modificada en el tratamiento del trastorno por déficit de atención/hiperactividad. Revista de Neurología, 55(6), 359-369.

Mejía, I. D., Arrebillaga, L., Avendaño, M. L. P., & Etchepareborda, M. (2013). El dilema del metilfenidato en el TDAH: Estudio de caso. Revista chilena de neuropsicología, 8(2), 50-57.

Nestler, E. J. (2004). Molecular mechanisms of drug addiction. Neuropharmacology, 47, 24-32.

Paolo Busardò, F., Kyriakou, C., Cipolloni, L., Zaami, S., & Frati, P. (2016). From clinical application to cognitive enhancement: The example of methylphenidate. Current Neuropharmacology, 14(1), 17-27.

Papaseit, E., García-Algar, O., Simó, S., Pichini, S., & Farré, M. (2013). Metilfenidato en el tratamiento del trastorno de déficit de atención con hiperactividad en pediatría: Monitorización en matrices biológicas. Anales de Pediatría, 78(2),

e1-123.e10. https://doi.org/10.1016/j.anpedi.2012.08.015

Patrick, K. S., & Straughn, A. B. (2016). Absorption differences between immediate-release dexmethylphenidate and dl-methylphenidate. Drug Metabolism and Disposition, 44(3), 418-421.

Pereira, S. V. D., Ferreira, A. M., Azevedo, A., Barroso, C., & Monteiro, V. (2018). Illicit use of Methylphenidate: The other side of the medical prescription. Birth and Growth Medical Journal, 27(2), 98-104.

Quinn, M., & Lynch, A. (2016). Is ADHD a ‘real’ disorder? Support for Learning, 31(1), 59-70.

Rabito-Alcón, M. F., & Correas-Lauffer, J. (2014). Treatment guidelines for attention deficit and hyperactivity disorder: A critical review. Actas Españolas de Psiquiatría, 42(6), 315-324.

Rastmanesh, R. (2010). Drug policy and treatment bias due to the dopamine-deficit theory of child attention-deficit hyperactivity disorder. ADHD Attention Deficit and Hyperactivity Disorders, 2(3), 149-157.

Ravi, M., & Ickowicz, A. (2016). Epilepsy, attention-deficit/hyperactivity disorder and methylphenidate: Critical examination of guiding evidence. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 25(1), 50-58.

Rezaei, G., Hosseini, S. A., Sari, A. A., Olyaeemanesh, A., Lotfi, M. H., Yassini, M., Bidaki, R., & Nouri, B. (2016). Comparative efficacy of methylphenidate and atomoxetine in the treatment of attention deficit hyperactivity disorder in children and adolescents: A systematic review and meta-analysis. Medical journal of the Islamic Republic of Iran, 30, 325. https://pubmed.ncbi.nlm.nih.gov/27390695/

Rubia, K., Halari, R., Cubillo, A., Smith, A. B., Mohammad, A.-M., Brammer, M., & Taylor, E. (2011). Methylphenidate normalizes fronto-striatal underactivation during interference inhibition in medication-naive boys with attention-deficit hyperactivity disorder. Neuropsychopharmacology, 36(8), 1575-1586.

Russell, V. A. (2011). Overview of animal models of attention deficit hyperactivity disorder (ADHD). Current Protocols in Neuroscience, 54(1), 9-35.

Saiz Fernández, L. C. (2018). Psicoestimulantes para el TDAH: Análisis integral para una medicina basada en la prudencia. Revista de la Asociación Española de Neuropsiquiatría, 38(133), 301-330.

Sallee, F. R., Palumbo, D. R., Abbas, R., Berry, S. A., Puthli, S. P., & Kathala, K. K. (2017). Effect of Food Intake on the Pharmacokinetics of a Novel Methylphenidate Extended-Release Oral Suspension for Attention Deficit Hyperactivity Disorder. Clinical Pharmacology in Drug Development, 6(5), 476-483.

Shin, J.-Y., Roughead, E. E., Park, B.-J., & Pratt, N. L. (2016). Cardiovascular safety of methylphenidate among children and young people with attention-deficit/ hyperactivity disorder (ADHD): Nationwide self controlled case series study. bmj, 353, i2550. https://doi.org/10.1136/bmj.i2550

Stahl, S. M., & Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications. Cambridge University Press.

Storebø, O. J., Ramstad, E., Krogh, H. B., Nilausen, T. D., Skoog, M., Holmskov, M., Rosendal, S., Groth, C., Magnusson, F. L., & Moreira-Maia, C. R. (2015). Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD). Cochrane Database of Systematic Reviews, 11.

Uddin, L. Q., Dajani, D. R., Voorhies, W., Bednarz, H., & Kana, R. K. (2017). Progress and roadblocks in the search for brain-based biomarkers of autism and attention-deficit/hyperactivity disorder. Translational psychiatry, 7(8), e1218. https:// doi.org/10.1038/tp.2017.164

Volkow, N. D. (2012). Long-term safety of stimulant use for ADHD: Findings from nonhuman primates. Neuropsychopharmacology, 37(12), 2551-2552.

Wenthur, C. J. (2016). Classics in chemical neuroscience: Methylphenidate. ACS chemical neuroscience, 7(8), 1030-1040.

Zagnoni, P. G., & Albano, C. (2002). Psychostimulants and epilepsy. Epilepsia, 43, 28-31.

Zahniser, N. R., & Sorkin, A. (2004). Rapid regulation of the dopamine transporter: Role in stimulant addiction? Neuropharmacology, 47, 80-91.

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Derechos de autor 2022 Juan Pablo Quintanilla Calvi, Guillermo Saúl Escobar Cornejo

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